貨號	規格	價格	上海	北京	武漢	南京
S80639-1mg	99.7%	￥102.00 S80639-1mg ￥102.00 現貨	10 10	-	-	-
S80639-5mg	99.7%	￥149.00 S80639-5mg ￥149.00 現貨	12 >10	-	-	-
S80639-10mg	99.7%	￥200.00 S80639-10mg ￥200.00 現貨	11 >10	-	-	-
S80639-25mg	99.7%	￥430.00 S80639-25mg ￥430.00 現貨	11 >10	-	-	-
S80639-50mg	99.7%	￥750.00 S80639-50mg ￥750.00 現貨	10 10	-	-	-
S80639-100mg	≥99%	￥1260.00 S80639-100mg ￥1260.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin?B, CK-II, PKA, and PKC, with all IC50s of >100 μM.

產品描述：

TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin?B, CK-II, PKA, and PKC, with all IC50s of >100 μM.

靶點：

GSK-3β:2 μM (IC50);GSK-3

體內研究：

TDZD-8 (TDZD8, 1?or 2?mg/kg, i.p.) both reduces the induction of p-DARPP32 following chronic L-dopa treatment in parkinsonian animals. TDZD8 treatment of 21 days induces a significant reduction in PKA expression in rats with established dyskinesia. Moreover, TDZD8 reduces FosB mRNA level in the striatum and lowers the expression of PPEB mRNA to similar levels as in 6-OHDA-lesioned rats without treated with L-dopa. The decrease in dyskinesia induced by TDZD8 is overcome by dopamine rceptor-1 agonist

參考文獻：

1. Martinez A, et al. First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem. 2002 Mar 14;45(6):1292-9. 2. Xie CL, et al. Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Sci Rep. 2016 Mar 21;6:23527.3. Sun A, et al. GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. Prostate. 2016 Feb;76(2):172-83.

溶解性：

DMSO : ≥ 100 mg/mL (449.92 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.499 ml	22.496 ml	44.992 ml
5 mM	0.9 ml	4.499 ml	8.998 ml
10 mM	0.45 ml	2.25 ml	4.499 ml
50 mM	0.09 ml	0.45 ml	0.9 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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