貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80583-10mg	99%	￥300.00 S80583-10mg ￥300.00 現(xiàn)貨	8 8	-	-	-
S80583-50mg	99%	￥600.00 S80583-50mg ￥600.00 現(xiàn)貨	8 8	-	-	-
S80583-250mg	99%	￥1200.00 S80583-250mg ￥1200.00 現(xiàn)貨	10 10	-	-	-
S80583-1g	99%	￥1900.00 S80583-1g ￥1900.00 現(xiàn)貨	7 7	-	-	-

產(chǎn)品介紹

Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease

產(chǎn)品描述：

靶點(diǎn)：

α1A-adrenoceptor;AdrenergicReceptor

體內(nèi)研究：

Nicergoline (10 mg/kg; i.v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease. Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice.

參考文獻(xiàn)：

1. Alvarez-Guerra, M., N. Bertholom, and R.P. Garay, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol, 1999. 13(1): p. 50-8. 2. Zang G, et, al. Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 2018 May;17(5):7293-7300. 3. Mizuno T, et, al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066(1-2):78-85.

溶解性：

DMSO : 100 mg/mL (206.45 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.064 ml	10.322 ml	20.645 ml
5 mM	0.413 ml	2.064 ml	4.129 ml
10 mM	0.206 ml	1.032 ml	2.064 ml
50 mM	0.041 ml	0.206 ml	0.413 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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Nicergoline