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產品描述： SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β. |
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靶點：
hGSK-3α:77.5 nM (IC50);hGSK-3β:77.5 nM (IC50);Apoptosis;GSK-3 |
參考文獻：
1. Coghlan MP, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol. 2000 Oct;7(10):793-803. 2. Pizarro JG, et al. Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci. 2008 May-Jun;26(3-4):269-76. 3. MacAulay K, et al. Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. Eur J Biochem. 2003 Sep;270(18):3829-38. |
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溶解性：
DMSO : 100 mg/mL (277.99 mM; Need ultrasonic) |
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保存條件：
-20℃ |
配置溶液濃度參考：
|
1mg |
5mg |
10mg |
| 1 mM |
2.78 ml |
13.9 ml |
27.799 ml |
| 5 mM |
0.556 ml |
2.78 ml |
5.56 ml |
| 10 mM |
0.278 ml |
1.39 ml |
2.78 ml |
| 50 mM |
0.056 ml |
0.278 ml |
0.556 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京