品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S80551-5mg	98%	￥552.50元	9	-	-	-
源葉(MedMol)	S80551-10mg	98%	￥1020.00元	6	-	-	-
源葉(MedMol)	S80551-25mg	98%	￥2040.00元	7	-	-	-
源葉(MedMol)	S80551-100mg	98%	￥5100.00元	2	-	-	-

產品介紹

BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively

產品描述： BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively

靶點： Ki: 0.31 μM (BEC hydrochloride, at pH 7.5) and 30 nM (BEC hydrochloride, at pH 9.5);Arginase

體外研究：
The X-ray crystal structure of the arginase-BEC complex has been determined at 2.3 ? resolution from crystals perfectly twinned by hemihedry. The structure of the complex reveals that the boronic acid moiety undergoes nucleophilic attack by metal-bridging hydroxide ion to yield a tetrahedral boronate anion that bridges the binuclear manganese cluster, thereby mimicking the tetrahedral intermediate (and its flanking transition states) in the arginine hydrolysis reaction.

體內研究：
Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness. Animal Model: C57BL/6J wild-type mice, mice deficient in arginase 2 (Arg2-/-), mice deficient in both arginase 1 and 2 (Arg1-/-Arg2-/-), and mice deficient in NOX2 (NOX2-/- Dosage: 20 mg/kg. Administration: I.V., in 0.9% saline, 1 hour before the injection of LPS. Result: BEC robustly reduced VEGF expression in neuroglia (72% reduction) and macrophage/microglia (87% reduction).

參考文獻：
1. Colleluori DM, et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62. 2. Kim NN, et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. 3. Ckless K, et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15;181(6):4255-64.

溶解性： Soluble in DMSO、H2O

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.357 ml	21.787 ml	43.575 ml
5 mM	0.871 ml	4.357 ml	8.715 ml
10 mM	0.436 ml	2.179 ml	4.357 ml
50 mM	0.087 ml	0.436 ml	0.871 ml

注意：

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BEC hydrochloride 98%

S-(2-boronoethyl)-L-cysteine hydrochloride