| 產品描述： | BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM |
| 靶點： |
NF-kB;IkB-α:10 μM (IC50);Apoptosis;IκB/IKK;Ferroptosis;NF-κB |
| 體內研究： |
BAY 11-7085 acts as an anti-inflammatory agent in both the rat carrageenan paw and the rat adjuvant arthritis model. It demonstrates a dose-dependent reduction in swelling in the rat carrageenan paw model |
| 參考文獻： |
1. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesionmolecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103. 2. Nasu K, et al. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E16-23. |
| 溶解性： |
DMSO : ≥ 26 mg/mL (104.28 mM) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) |
| 保存條件： |
RT |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.011 ml |
20.054 ml |
40.107 ml |
| 5 mM |
0.802 ml |
4.011 ml |
8.021 ml |
| 10 mM |
0.401 ml |
2.005 ml |
4.011 ml |
| 50 mM |
0.08 ml |
0.401 ml |
0.802 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京