| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S80489-5mg |
99.4% | ￥204.00 | 5 | - | - | - |
|
S80489-10mg |
99.4% | ￥340.00 | 7 | - | - | - |
|
S80489-25mg |
99.4% | ￥520.00 | 7 | - | - | - |
|
S80489-50mg |
≥98% | ￥740.00 | 貨期：2-3天 | - | - | - |
|
S80489-100mg |
≥98% | ￥1200.00 | 貨期：2-3天 | - | - | - |
|
S80489-200mg |
≥98% | ￥2100.00 | 貨期：2-3天 | - | - | - |
|
PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.
| 產品描述： | PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | EGFR:6 pM (Ki);EGFR:25 pM (IC50);EGFR | ||||||||||||||||||||
| 體內研究： | PD153035 levels in the plasma and tumor rise to 50 and 22 μM within 15 minutes following a single i.p. dose of 80 mg/kg. While the plasma levels of PD 153035 falls below 1 μM by 3 hours, in the tumors it remains at micromolar concentrations for at least 12 hours. The tyrosine phosphorylation of the EGF receptor is rapidly suppressed by 80-90% in the tumors | ||||||||||||||||||||
| 參考文獻： | 1. Bridges AJ, et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76. 2. Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265(5175):1093-5. 3. Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106. 4. Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302. | ||||||||||||||||||||
| 溶解性： | DMSO : 5.125 mg/mL (12.92 mM; Need ultrasonic and warming) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京