貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80444-5mg	99.8%	￥240.00 S80444-5mg ￥240.00 現(xiàn)貨	7 7	-	-	-
S80444-10mg	99.8%	￥376.00 S80444-10mg ￥376.00 現(xiàn)貨	6 6	-	-	-
S80444-25mg	99.8%	￥760.00 S80444-25mg ￥760.00 現(xiàn)貨	4 4	-	-	-
S80444-50mg	99.8%	￥1280.00 S80444-50mg ￥1280.00 現(xiàn)貨	5 5	-	-	-
S80444-100mg	99.8%	￥2240.00 S80444-100mg ￥2240.00 現(xiàn)貨	2 2	-	-	-
S80444-250mg	99.8%	￥3600.00 S80444-250mg ￥3600.00 現(xiàn)貨	4 4	-	-	-

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產(chǎn)品介紹

Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 μM for ACAT1 and ACAT2, respectively. Avasimibe can be used for the research of prostate cancer

產(chǎn)品描述：

靶點(diǎn)：

ACAT1:24 μM (IC50)；ACAT2：9.2 μM (IC50);P450;Acyltransferase

體內(nèi)研究：

Avasimibe (30 mg/kg, intraperitoneally injected on alternate days for 7 weeks) suppresses PCa cell growth and metastasis in vivo. Avasimibe has good biocompatibility and low toxicity

參考文獻(xiàn)：

1. Taichi Ohshiro,et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. 2. Kangping Xiong, et al. The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer.Cancer Cell Int. 2021 Aug 30;21(1):461.

溶解性：

DMSO : 100 mg/mL (199.31 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.993 ml	9.966 ml	19.931 ml
5 mM	0.399 ml	1.993 ml	3.986 ml
10 mM	0.199 ml	0.997 ml	1.993 ml
50 mM	0.04 ml	0.199 ml	0.399 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)(1篇)

1. [IF=3.4] Zhiquan Wang et al."A study on cholesterol-cholesteryl ester metabolic homeostasis and drug intervention in hyperlipidemic hamsters using UHPLC-MS/MS."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2024 Mar;240:115933

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