貨號	規格	價格	上海	北京	武漢	南京
S80325-2mg	≥98%	￥360.00 S80325-2mg ￥360.00 2-3天	0 貨期：2-3天	-	-	-
S80325-5mg	≥98%	￥700.00 S80325-5mg ￥700.00 2-3天	0 貨期：2-3天	-	-	-
S80325-10mg	≥98%	￥1250.00 S80325-10mg ￥1250.00 2-3天	0 貨期：2-3天	-	-	-
S80325-25mg	≥98%	￥2520.00 S80325-25mg ￥2520.00 2-3天	0 貨期：2-3天	-	-	-
S80325-100mg	≥98%	￥8540.00 S80325-100mg ￥8540.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity

產品描述：

GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity

靶點：

Histone Demethylase;HistoneDemethylase

體內研究：

GSK2879552 (1.5 mg/kg, p.o.) treatment exhibits tumor growth inhibition in SCLC xenograft bearing mice. Animal Model: NCI-H526 and NCI-H1417 xenografts. Dosage: 1.5 mg/kg. Administration: PO daily for 25-35 days. Result: There was 57% and 83% tumor growth inhibition (TGI) in NCI-H526 and NCI-H1417 tumor bearing mice respectively. NCI-H510 and NCI-H69 tumor bearing mice also demonstrated partial TGI (38% and 49% respectively) in response to GSK2879552, while no significant TGI was observed for SHP77 bearing mice.

參考文獻：

1. Huang M, et al. Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett. 2017 Apr 2;398:12-21 2. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.744 ml	13.718 ml	27.436 ml
5 mM	0.549 ml	2.744 ml	5.487 ml
10 mM	0.274 ml	1.372 ml	2.744 ml
50 mM	0.055 ml	0.274 ml	0.549 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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