貨號	規格	價格	上海	北京	武漢	南京
S80315-5mg	99.2%	￥240.00 S80315-5mg ￥240.00 現貨	5 5	-	-	-
S80315-10mg	99.2%	￥340.00 S80315-10mg ￥340.00 現貨	6 6	-	-	-
S80315-50mg	99.2%	￥800.00 S80315-50mg ￥800.00 現貨	2 2	-	-	-

產品介紹

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

產品描述：

靶點：

PKC-α:5 nM (IC50);PKC-βI:24 nM (IC50);PKC-βII:14 nM (IC50);PKC-γ:27 nM (IC50);PKC-ε:24 nM (IC50);Rat Brain PKC:23 nM (IC50);MAPKAP-K1b:3 nM (IC50);MSK1:8 nM (IC50);S6K1:15 nM (IC50);GSK3β:38 nM (IC50);PKC

體內研究：

Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP?/? mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change

參考文獻：

1. Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 (Pt 2):335-7. 2. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. 3. Tian F, et al. Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology. 2007 Jul;28(4):843-9. Epub 2007 Apr 20. 4. Hambleton M, et al. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation. 2006 Aug 8;114(6):574-82.

溶解性：

DMSO : 35.71 mg/mL (64.50 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.806 ml	9.031 ml	18.062 ml
5 mM	0.361 ml	1.806 ml	3.612 ml
10 mM	0.181 ml	0.903 ml	1.806 ml
50 mM	0.036 ml	0.181 ml	0.361 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Ro 31-8220 Mesylate