貨號	規格	價格	上海	北京	武漢	南京
S80285-5mg	98.6%	￥530.00 S80285-5mg ￥530.00 現貨	6 6	-	-	-
S80285-10mg	98.6%	￥850.00 S80285-10mg ￥850.00 現貨	6 6	-	-	-
S80285-25mg	98.6%	￥1700.00 S80285-25mg ￥1700.00 現貨	6 6	-	-	-
S80285-100mg	≥98%	￥5100.00 S80285-100mg ￥5100.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

TP-0903 is a potent and selective Axl kinase inhibitor.

產品描述：

TP-0903 is a potent and selective Axl kinase inhibitor.

靶點：

Apoptosis;TAM Receptor;Apoptosis;TAMReceptor

體外研究：

In pancreatic cancer cells (PSN-1), TP-0903 shows strong antiproliferative activity with IC50 of 6 M. TP-0903 also induces strong G2/M arrest by potently inhibiting Aurora A and B. In CLL B cells from all the patients with CLL, TP-0903 causes a dose-dependent induction of massive apoptosis by targeting phosphorylated Axl, and overcomes CLL BMSC-mediated protection of CLL B cells from apoptosis.

體內研究：

In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.

細胞實驗：

For cell proliferation assays, 45 μL containing 1000 cells per well are seeded into solid white 384-well plates in appropriate media. The following day, TP-0903 is diluted in serum free growth media to 10x desired concentrations and 5 μL is added to each well. Combined compound and cells are incubated for 96 hours. Following incubation, 40 μL of ATP-Lite solution is added to each well, incubated for an additional 10 minutes at room temperature and luminescence is measured on an microplate reader

參考文獻：

1. Mollard A, Warner SL, Call LT, Wade ML, Bearss JJ, Verma A, Sharma S, Vankayalapati H, Bearss DJ. Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors. ACS Med Chem Lett. 2011 Dec 8;2(12):907-912. 2. Sinha S, et al. Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors. Clin Cancer Res. 2015, 21(9), 2115-2126.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.938 ml	9.689 ml	19.378 ml
5 mM	0.388 ml	1.938 ml	3.876 ml
10 mM	0.194 ml	0.969 ml	1.938 ml
50 mM	0.039 ml	0.194 ml	0.388 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Dubermatinib

TP-0903