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ENMD-2076 L-(+)-Tartaric acid

    98%

ENMD-2076 L-(+)-Tartaric acid

源葉(MedMol)
S80256
1291074-87-7
C25H31N7O6
525.56
ENMD-2076 酒石酸鹽
品牌 貨號 產品規格 價格(RMB) 庫存(上海) 北京 武漢 南京 購買數量
源葉(MedMol) S80256-5mg 98% ¥320.00元 7 - - -
源葉(MedMol) S80256-10mg 98% ¥578.00元 6 - - -
源葉(MedMol) S80256-50mg 98% ¥1300.00元 2 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
產品描述: ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
靶點: Aurora A:1.86 nM (IC50);KDR:58.2 nM (IC50);Flt-4:15.9 nM (IC50);FGFR1:92.7 nM (IC50);FGFR2:70.8 nM (IC50);PDGFRα:56.4 nM (IC50);Flt3:14 nM (IC50)
體內研究: ENMD-2076 treatment results in statistically significant, dose dependent inhibition of tumor growth or tumor regression. Moreover, there is no correlation between tumor growth rate and antitumor efficacy, which would conceivably be expected for a mitotic kinase inhibitor, as fast growing (e.g., A375 melanoma) and slow-growing (e.g., HT29 colon carcinoma) tumors are similarly inhibited by ENMD-2076. ENMD-2076 is well tolerated at daily doses up to 302 mg/kg (equivalent to 200 mg/kg of the free base), with no weight loss or signs of morbidity noted in any study at this dose with the exception of the A375 model
參考文獻: 1. Fletcher GC, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37. 2. Wang X, et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25.
溶解性: Soluble  in  DMSO
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.903 ml 9.514 ml 19.027 ml
5 mM 0.381 ml 1.903 ml 3.805 ml
10 mM 0.19 ml 0.951 ml 1.903 ml
50 mM 0.038 ml 0.19 ml 0.381 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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摩爾濃度計算器

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