| 產(chǎn)品描述： | Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) |
| 靶點(diǎn)： |
5-HT3 Receptor：0.33 nM (IC50);5-HTReceptor |
| 體內(nèi)研究： |
Azasetron could effectively penetrate through the skin and pass into the systemic circulation |
| 參考文獻(xiàn)： |
1. Sato, N., et al., Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn J Pharmacol, 1992. 59(4): p. 443-8. 2. Haga, K., et al., The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. Jpn J Pharmacol, 1993. 63(3): p. 377-83. |
| 溶解性： |
H2O : 20 mg/mL (51.78 mM; Need ultrasonic) DMSO : 2.22 mg/mL (5.75 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.589 ml |
12.944 ml |
25.889 ml |
| 5 mM |
0.518 ml |
2.589 ml |
5.178 ml |
| 10 mM |
0.259 ml |
1.294 ml |
2.589 ml |
| 50 mM |
0.052 ml |
0.259 ml |
0.518 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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