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產品描述： (-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects |
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靶點：
Ki: 211.7 nM (N-methyl-D-aspartate (NMDA) receptor);NMDAR;iGluR |
體內研究：
(-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model |
參考文獻：
1. Yang B, et al. Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model. Int J Neuropsychopharmacol. 2016 Dec 30;19(12). 2. Nishimura M, et al. MK-801 blocks monoamine transporters expressed in HEK cells. FEBS Lett. 1998 Feb 27;423(3):376-80. |
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溶解性：
DMSO : 100 mg/mL (296.41 mM; Need ultrasonic) Ethanol : 25 mg/mL (74.10 mM; Need ultrasonic) H2O : 8.33 mg/mL (24.69 mM; ultrasonic and warming and heat to 60°C) |
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保存條件：
-20℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.964 ml |
14.821 ml |
29.641 ml |
| 5 mM |
0.593 ml |
2.964 ml |
5.928 ml |
| 10 mM |
0.296 ml |
1.482 ml |
2.964 ml |
| 50 mM |
0.059 ml |
0.296 ml |
0.593 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
北京