品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S80118-1mg	98%	￥200.00元	3	-	-	-
源葉(MedMol)	S80118-2mg	98%	￥320.00元	10	-	-	-
源葉(MedMol)	S80118-5mg	98%	￥400.00元	6	-	-	-
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源葉(MedMol)	S80118-25mg	98%	￥1520.00元	2	-	-	-
源葉(MedMol)	S80118-50mg	98%	￥2800.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S80118-100mg	98%	￥5120.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹

CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively

產(chǎn)品描述： CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively

靶點(diǎn)： IC50: 54 nM (rRNA synthesis, MIA PaCa-2 cells), 113 nM (rRNA synthesis, A375 cells), 142 nM (rRNA synthesis, HCT-116 cells);DNA/RNASynthesis

體內(nèi)研究：
CX-5461 displays antitumor activity against human solid tumors in murine xenograft models. CX-5461 (50 mg/kg, p.o.) shows significant MIA PaCa-2 growth inhibition with TGI equal to 69% on day 31 and 79% TGI on A375 on day 32. CX-5461 (50 mg/kg, p.o.) inhibits the Eμ-Myc tumor cells with 84% repression in Pol I transcription at 1 hr posttreatment in C57BL/6 mice. CX-5461 also induces a rapid reduction in tumor burden in the lymph nodes and a concomitant reduction of spleen size to within the normal range

參考文獻(xiàn)：
1. Drygin D et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res. 2011 Feb 15;71(4):1418-30. 2. Bywater MJ, et al. Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53. Cancer Cell. 2012 Jul 10;22(1):51-65.

溶解性： 50 mM sodium phosphate (pH 3.5) : 10 mg/mL (19.47 mM; Need ultrasonic) DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.947 ml	9.735 ml	19.47 ml
5 mM	0.389 ml	1.947 ml	3.894 ml
10 mM	0.195 ml	0.974 ml	1.947 ml
50 mM	0.039 ml	0.195 ml	0.389 ml

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部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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