品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S80101-5mg	≥98%	￥703.00元	2	-	-	-
源葉(MedMol)	S80101-10mg	≥98%	￥1111.00元	5	-	-	-
源葉(MedMol)	S80101-25mg	≥98%	￥2409.00元	3	-	-	-
源葉(MedMol)	S80101-50mg	≥98%	￥4077.00元	3	-	-	-
源葉(MedMol)	S80101-100mg	≥98%	￥6951.00元	2	-	-	-

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產(chǎn)品介紹

GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits ALK with an IC50 of 0.5 nM

產(chǎn)品描述：

GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits ALK with an IC50 of 0.5 nM

靶點(diǎn)：

IC50: 2.0 nM (IGF-IR), 1.6 nM (insulin receptor), 0.5 nM (ALK);IGF-1R;JNK;S6Kinase;ALK

體內(nèi)研究：

GSK1838705A shows robust antitumor activity in animal xenograft models. Tumor types likely to respond to GSK1838705A include multiple myeloma and Ewing's sarcoma, as well as ALK-driven tumors (e.g., ALCL, NSCLC, and neuroblastoma). A single oral dose of GSK1838705A at 0.1 and 0.3 mg/kg results in 35% and 65% inhibition of IGF-IR phosphorylation, respectively, whereas doses ≥1 mg/kg results in complete inhibition of ligand-induced IGF-IR phosphorylation

參考文獻(xiàn)：

1. Sabbatini P, et al. GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.878 ml	9.388 ml	18.777 ml
5 mM	0.376 ml	1.878 ml	3.755 ml
10 mM	0.188 ml	0.939 ml	1.878 ml
50 mM	0.038 ml	0.188 ml	0.376 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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GSK1838705A ≥98%

GSK1838705A