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產品描述： Sertindole (Lu 23-174) is an orally active?5-HT2A,?5-HT2C,?dopamine D2, and?αl-adrenergic?receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple?cancer?cells. |
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靶點：
5-HT2A Receptor;5-HT2C Receptor;DopamineReceptor;5-HTReceptor;AdrenergicReceptor;Autophagy |
體內研究：
Sertindole (oral gavage; 10?mg/kg; once daily; 12 d) shows anti-tumor activity in vivo |
參考文獻：
1. David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. 2. Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753. 3. Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85. |
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溶解性：
DMSO : 25 mg/mL (56.70 mM; Need ultrasonic) |
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保存條件：
-20℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.268 ml |
11.339 ml |
22.679 ml |
| 5 mM |
0.454 ml |
2.268 ml |
4.536 ml |
| 10 mM |
0.227 ml |
1.134 ml |
2.268 ml |
| 50 mM |
0.045 ml |
0.227 ml |
0.454 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
北京