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MK-2206 2HCl

    
99%

MK-2206 dihydrochloride

源葉(MedMol)
S80038 一鍵復(fù)制產(chǎn)品信息
1032350-13-2
C25H21N5O·2HCl
480.39
8-[4-(1-氨基環(huán)丁基)苯基]-9-苯基-1,2,4-三唑并[3,4-f][1,6]萘啶-3(2H)-酮二鹽酸鹽;8-[4-(1-氨基環(huán)丁基)苯基]-9-苯基-1,2,4-噻唑并[3,4-f][1,6]萘啶-3(2H)-酮雙鹽酸鹽
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購買數(shù)量
S80038-1mg 99% ¥224.00 8 - - -
S80038-5mg 99% ¥400.00 5 - - -
S80038-10mg 99% ¥600.00 5 - - -
S80038-25mg 99% ¥1160.00 5 - - -
S80038-50mg 99% ¥1600.00 3 - - -
S80038-100mg 99% ¥2640.00 6 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active allosteric AKT inhibitor with IC50s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy

產(chǎn)品描述: MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active allosteric AKT inhibitor with IC50s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy
靶點(diǎn): Akt1:8 nM (IC50);Akt2:12 nM (IC50);Akt3:65 nM (IC50);Apoptosis;Akt;Autophagy
體內(nèi)研究: Both MK-2206 dihydrochloride (MK-2206 (2HCl)) doses (oral gavage; 480 mg/kg once a week and 240 mg/kg three times a week; for 2 weeks) can inhibit the growth of human CNE-2 xenografts in nude mice. No other obvious toxicity is observed in mice. MK-2206 dihydrochloride (orally; 120 mg/kg; alternate days; for 3 weeks) significantly inhibits tumor growth in 3-5 week old athymic nude mice with GEO colon carcinoma cells.
參考文獻(xiàn): 1. Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009.2. Xing Y, et al. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Res. 2019 Jul 5;21(1):78.3. Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37.4. Agarwal E, et al. Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. BMC Cancer. 2014 Mar 1;14:145.
溶解性: DMSO  :  16.67  mg/mL  (34.70  mM;  ultrasonic  and  warming  and  heat  to  70°C)    H2O  :  3.57  mg/mL  (7.43  mM;  ultrasonic  and  warming  and  heat  to  60°C)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.082 ml 10.408 ml 20.816 ml
5 mM 0.416 ml 2.082 ml 4.163 ml
10 mM 0.208 ml 1.041 ml 2.082 ml
50 mM 0.042 ml 0.208 ml 0.416 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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摩爾濃度計(jì)算器

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