品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S80036-5mg	≥98%	￥452.00元	>10	-	-	-
源葉(MedMol)	S80036-10mg	≥98%	￥650.00元	>10	-	-	-
源葉(MedMol)	S80036-50mg	≥98%	￥2104.00元	>10	-	-	-

產(chǎn)品介紹

MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy

產(chǎn)品描述： MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy

靶點(diǎn)： IC50: 1 nM (human SCD1), 3 nM (rat SCD1), 3 nM (mouse SCD1);Dehydrogenase;Stearoyl-CoADesaturase(SCD)

體內(nèi)研究：
MK-8245 (10mg/kg; p.o.) exhibits a tissue distribution profile concentrated in the liver, with low exposure in tissues associated with potential adverse events in rats, dogs, and rhesus monkeys. MK-8245 improves glucose clearance in a dose-dependent manner in eDIO mice administrated before the glucose challenge

參考文獻(xiàn)：
1. Oballa RM, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.J Med Chem. 2011 Jul 28;54(14):5082-96. Epub 2011 Jun 28.

溶解性： Soluble in DMSO

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.14 ml	10.701 ml	21.401 ml
5 mM	0.428 ml	2.14 ml	4.28 ml
10 mM	0.214 ml	1.07 ml	2.14 ml
50 mM	0.043 ml	0.214 ml	0.428 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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MK-8245 ≥98%

MK-8245