品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S80029-1mg	98%	￥100.00元	5	-	-	-
源葉(MedMol)	S80029-2mg	98%	￥140.00元	6	-	-	-
源葉(MedMol)	S80029-5mg	98%	￥170.00元	5	-	-	-
源葉(MedMol)	S80029-10mg	98%	￥180.00元	5	-	-	-
源葉(MedMol)	S80029-25mg	98%	￥400.00元	4	-	-	-
源葉(MedMol)	S80029-50mg	98%	￥610.00元	預(yù)計(jì)交期：2-3天	-	-	-
源葉(MedMol)	S80029-100mg	98%	￥990.00元	預(yù)計(jì)交期：2-3天	-	-	-

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產(chǎn)品介紹

Fostamatinib Disodium (R788 Disodium) is the oral prodrug of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)

產(chǎn)品描述： Fostamatinib Disodium (R788 Disodium) is the oral prodrug of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)

靶點(diǎn)： Syk, FLT3;FLT;Syk

體內(nèi)研究：
Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406

參考文獻(xiàn)：
1. Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273. 2. Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. 3. Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.

溶解性： DMSO : 20.83 mg/mL (33.36 mM; ultrasonic and warming and heat to 60°C) H2O : ≥ 1 mg/mL (1.60 mM)

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.601 ml	8.007 ml	16.015 ml
5 mM	0.32 ml	1.601 ml	3.203 ml
10 mM	0.16 ml	0.801 ml	1.601 ml
50 mM	0.032 ml	0.16 ml	0.32 ml

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部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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R788 (Fostamatinib) Disodium 98%

R788 (Fostamatinib) Disodium