貨號	規格	價格	上海	北京	武漢	南京
S23474-5mg	98%	￥240.00 S23474-5mg ￥240.00 現貨	6 6	-	-	-
S23474-10mg	98%	￥390.00 S23474-10mg ￥390.00 現貨	7 7	-	-	-
S23474-25mg	98%	￥760.00 S23474-25mg ￥760.00 現貨	6 6	-	-	-
S23474-50mg	98%	￥1320.00 S23474-50mg ￥1320.00 現貨	5 5	-	-	-

產品介紹

AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects

產品描述：

靶點：

PI3Kγ:70 nM (IC50);PI3Kα:240 nM (IC50);PI3Kβ:1.4 μM (IC50);PI3Kδ:1.7 μM (IC50);PI3K

體內研究：

AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema. AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. Animal Model: Male Wistar rats (100-150 g) injected with carrageenan Dosage: 10 mg/kg, 30 mg/kg, 100 mg/kg Administration: Oral administration; once Result: Induced a significant reduction of paw thickness.

參考文獻：

1. Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322(3):923-30.

溶解性：

Soluble in DMSO

保存條件：

2-8°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.012 ml	20.061 ml	40.122 ml
5 mM	0.802 ml	4.012 ml	8.024 ml
10 mM	0.401 ml	2.006 ml	4.012 ml
50 mM	0.08 ml	0.401 ml	0.802 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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AS-041164