103. [IF=13.2] Pengpeng Guan et al."Multifunctional magnetic MOF under cover of erythrocytes for ROS scavenging and magnetic hyperthermia thrombolysis."CHEMICAL ENGINEERING JOURNAL.2025 Jul;515:163939 102. [IF=7.7] Yuan Ji et al."Rapid hemostatic covered stent with drug-loaded gelatin-alginate/PVDF Janus composite membrane for coronary artery perforation."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;:136889 101. [IF=8.2] Wei Chen et al."3D bioprinted in vitro epilepsy models for pharmacological evaluation in temporal lobe epilepsy."Biofabrication.2024 Oct;: 100. [IF=4] Yuan Li et al."Modification of the active centre of nattokinase to enhance its thermostability using a strategy based on molecular dynamics simulation, steered dynamics simulation, and conservative prediction."Frontiers in Nutrition.2024 Nov;11: 99. [IF=4.4] Xiaoyu Chai et al."Identification, screening, and comprehensive evaluation of novel thrombin inhibitory peptides from the hirudo produced using pepsin."Frontiers in Pharmacology.2024 Nov;15: 98. [IF=4.9] Xin Jin et al."The CRISPR/Cas system-mediated function of Hg2+ on urease activity for colorimetric detection of the tumor biomarker in clinical samples."MICROCHEMICAL JOURNAL.2024 Nov;:112317 97. [IF=13] Zhenghui Shi et al."Artificial Plateletoids Recruit Blood Proteins to Shield Symbiotic Thrombin: a Silk Fibroin/Calcium Interface Medicated Thrombin Generation and Preservation."Small.2024 Dec;:2406909 96. [IF=13.3] Han Zhang et al."Dual-functional improvement of vascularization and bone formation of complementary PRP-based gel scaffold."CHEMICAL ENGINEERING JOURNAL.2025 Jan;:159512 95. [IF=4.8] Xuan Xin et al."Efficient hydrolysis of coagulated porcine blood by a purified lumbrokinase from Eisenia fetida."Food Bioscience.2025 Apr;:106655 94. [IF=27.4] Yuqiong Xia et al."Phosphatidylcholine Liposome Accelerated Platinum Nanomachines (PLANEs) With Enhanced Penetration Capability for Thrombus Mechanotherapy."ADVANCED MATERIALS.2025 Apr;:2418590 93. [IF=5.1] Mengqian Chen et al."Inhibitory mechanism study of soyasaponins on thrombin: extraction, purification, and functional property analysis."Food & Function.2025 Apr;: 92. [IF=12.8] Yang Zhang et al."Osteoclasts drive bone formation in ectopic and orthotopic environments."BIOMATERIALS.2025 Apr;:123377 91. [IF=5.4] Nan Lv et al."Enhanced-permeability delivery system for hydroxyl radical-responsive NIR-II fluorescence-monitored thrombolytic therapy."COLLOIDS AND SURFACES B-BIOINTERFACES.2025 Jan;245:114193 90. [IF=10] Ke Gai et al."Development of Neural Cells and Spontaneous Neural Activities in Engineered Brain-Like Constructs for Transplantation."Advanced Healthcare Materials.2024 Sep;:2401419 89. [IF=3.7] Xuewei Du et al."Ferricyanide-Mediated, Electrocatalytic Mechanism of Electrochemical Aptamer-Based Sensor Supports Ultrasensitive Analysis of Cardiac Troponin I in Clinical Samples."LANGMUIR.2024;40(34):18214–18224 88. [IF=4.2] Fengmin Xiong et al."Fusion protein of FGF21 and elastin-like peptide improves wound healing in diabetic mice via inflammation modulation, collagen synthesis, and vascular network formation."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Nov;982:176953 87. [IF=10.7] Lianqi Shan et al."Drug delivery under cover of erythrocytes extends drug half-life: A thrombolytic targeting therapy utilizing microenvironment-responsive artificial polysaccharide microvesicles."CARBOHYDRATE POLYMERS.2024 Nov;343:122505 86. [IF=2.6] Si-Miao Yu et al."Chemoproteomic strategy identifies PfUCHL3 as the target of halofuginone."CHEMBIOCHEM.2024 Jun;:e202400269 85. [IF=8.3] Xinyu Wang et al."Dual-Responsive Microsphere Based on Natural Sunflower Pollen for Hemostasis and Repair in Inflammatory Bowel Disease."ACS Applied Materials & Interfaces.2024;XXXX(XXX):XXX-XXX 84. [IF=4.4] Zhe Jiao et al."Highly-Selective fluorescent Fe3O4@PPy aptasensor."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY".2024 Oct;318:124447 83. [IF=2.1] Hongwen Yang et al."Intrauterine infusion of platelet‐rich plasma improves fibrosis by transforming growth factor beta 1/Smad pathway in a rat intrauterine adhesion model."Reproductive Biology".2024 Jun;24:100882 82. [IF=6.1] Yaran Zhang et al."A simple, rapid and sensitive sandwich immunoassay based on poly(N-isopropylacrylamide) for the detection of alpha-fetoprotein."TALANTA".2024 Jul;274:125932 81. [IF=11.2] Caijie Yuan et al."Thrombotic microenvironment responsive crosslinking cyclodextrin metal-organic framework nanocarriers for precise targeting and thrombolysis."CARBOHYDRATE POLYMERS".2024 Jun;334:122058 80. [IF=24.1] Tan Suiyi et al."gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity."Cellular & Molecular Immunology".2024 Mar;:1-16 79. [IF=2.5] Li Xidong et al."Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker."International Journal of Peptide Research and Therapeutics".2024 Mar;30(2):1-15 78. [IF=15.1] Xiangrong Yu et al."High Intensity Focused Ultrasound-Driven Nanomotor for Effective Ferroptosis-Immunotherapy of TNBC."Advanced Science".2024 Feb;:2305546 77. [IF=25] Xurui Liu et al."Magnetic soft microfiberbots for robotic embolization."Science Robotics".2024 Feb;9(87) 76. [IF=5.7] Gan Wang et al."Engineered three-dimensional bioactive scaffold for enhanced bone regeneration through modulating transplanted adipose derived mesenchymal stem cell and stimulating angiogenesis."Frontiers in Bioengineering and Biotechnology.2024; 12: 13425 75. [IF=8.2] Ruyu Wang et al."Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.20 74. [IF=4.3] Zou Rong et al."Transistor-based immunosensor using AuNPs-Ab2-HRP enzyme nanoprobe for the detection of antigen biomarker in human blood."ANALYTICAL AND BIOANALYTICAL CHEMISTRY.2023 Nov;:1-11 73. [IF=5.7] Liu Jinying et al."Multi-signal aptasensor for thrombin detection based on catalytically active gold nanoparticles and fluorescent silicon quantum dots."MICROCHIMICA ACTA.2023 Nov;190(11):1-12 72. [IF=15.1] Ming Li et al."Distinguishable Colorimetric Biosensor for Diagnosis of Prostate Cancer Bone Metastases."Advanced Science.2023 Oct;10(32):2303159 71. [IF=8.2] Jingwen Tang et al."Highly absorbent bio-sponge based on carboxymethyl chitosan/poly-γ-glutamic acid/platelet-rich plasma for hemostasis and wound healing."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Jul;:125754 70. [IF=5.743] Zehao Wang et al."In-Situ Fabrication of Electroactive Cu2+-Trithiocyanate Complex and Its Application for Label-Free Electrochemical Aptasensing of Thrombin."Biosensors-Basel.2023 May;13(5):532 69. [IF=15.717] Shunli Wu et al."Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair."Materials Horizons.2023 May;: 68. [IF=0] Man Zhu et al."Employing a Redox Reporter-Modified Self-Assembly Monolayer in Electrochemical Aptamer-Based Sensors to Enable Calibration-Free Measurements."ACS Applied Bio Materials.2023;XXXX(XXX):XXX-XXX 67. [IF=5.304] Zhiwei Liu et al."Hemin-catalyzed SI-RAFT polymerization for thrombin detection."MICROCHEMICAL JOURNAL.2023 Feb;:108521 66. [IF=5.999] Ting Wang et al."Sodium alginate hydrogel containing platelet-rich plasma?for wound healing."COLLOIDS AND SURFACES B-BIOINTERFACES.2023 Feb;222:113096 65. [IF=8.008] Shuang Xia et al."Paper-Based Distance Sensor for the Detection of Lipase via a Phase Separation-Induced Viscosity Change."ANALYTICAL CHEMISTRY.2022;XXXX(XXX):XXX-XXX 64. [IF=3.21] Man Zhu et al."Incorporation of a Multi-Valent Aptamer into Electrochemical Biosensors to Achieve an Improved Performance for Thrombin Analysis in Blood Serum."ChemPlusChem.2022 Nov;87(11):e202200325 63. [IF=6.269] Jing Chen et al."A natural heparinoid from mollusc Meretrix lusoria: Purification, structural characterization, and antithrombotic evaluation."Current Research in Food Science.2022 Oct;: 62. [IF=5.561] Yuan Li et al."Characterization of a Nattokinase from the Newly Isolated Bile Salt-Resistant Bacillus mojavensis LY-06."Foods.2022 Jan;11(16):2403 61. [IF=10.383] Songzhi Xie et al."Bacteria-Templated and Dual Enzyme-Powered Microcapsule Motors To Promote Thrombus Penetration and Thrombolytic Efficacy."ACS Applied Materials & Interfaces.2022;14(33):37553–37565 60. [IF=4.927] Yunxiao Feng et al."Fluorescent Immunoassay with a Copper Polymer as the Signal Label for Catalytic Oxidation of O-Phenylenediamine."MOLECULES.2022 Jan;27(12):3675 59. [IF=2.464] Weiwei Luo et al."A sensitive electrochemiluminescent sensor chip based on the ssDNA-Ru(II) complex and aptamer for the determination of thrombin."LUMINESCENCE 58. [IF=2.891] Yunxiao Feng et al."A General, Label-Free and Homogeneous Electrochemical Strategy for Probing of Protease Activity and Screening of Inhibitor."Micromachines. 2022 May;13(5):803 57. [IF=2.162] Yajie Duan et al."Production, purification and characterization of a novel antithrombotic and anticoagulant serine protease from food grade microorganism Neurospora crassa."Preparative Biochemistry & Biotechnology. 2022 Jan 09 56. [IF=9.381] Fan Leng et al."Size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres for endovascular embolization."Carbohyd Polym. 2022 Jun;286:119274 55. [IF=6.057] Ghazala Ashraf et al."Extension of duplex specific nuclease sensing application with RNA aptamer."Talanta. 2022 May;242:123314 54. [IF=6.475] Juanjuan Du et al."Insight into the mechanism of myosin-fibrin gelation induced by non-disulfide covalent cross-linking."Food Res Int. 2022 Jun;156:111168 53. [IF=13.281] Ting Li et al.Engineered Platelet-Based Micro/Nanomotors for Cancer Therapy.Small.2021 Nov 05 52. [IF=4.142] Qu Fei et al."Ratiometric detection of alkaline phosphatase based on aggregation-induced emission enhancement."Anal Bioanal Chem. 2019 Nov;411(28):7431-7440 51. [IF=4.952] Juanjuan Du et al."The effect of fibrin on rheological behavior, gelling properties and microstructure of myofibrillar proteins."Lwt Food Sci Technol. 2022 Jan;153:112457 50. [IF=5.118] ZhenXing Du et al."Isolation and Characterization of a Heparin-Like Compound with Potent Anticoagulant and Fibrinolytic Activity from the Clam Coelomactra antiquata."Mar Drugs. 2020 Jan;18(1):6 49. [IF=5.89] Bingchuan Lu et al."Rapid Fabrication of Cell-Laden Microfibers for Construction of Aligned Biomimetic Tissue."Front Bioeng Biotech. 2020; 8: 610249 48. [IF=6.057] Yu Xin Liu et al."DNA nanosheet as an excellent fluorescence anisotropy amplification platform for accurate and sensitive biosensing."Talanta. 2020 May;211:120730 47. [IF=6.558] Wenjing Qi et al."Electrochemiluminescence resonance energy transfer immunoassay for alkaline phosphatase using p-nitrophenyl phosphate as substrate."Anal Chim Acta. 2020 Feb;1097:71 46. [IF=6.843] Yuting Shi et al."Preparation and application of quick hemostatic gauze based on biomimetic mineralized thrombin."Biomater Sci-Uk. 2021 Sep;9(18):6098-6107 45. [IF=7.514] Xin Zheng et al."Identification of the functional food ingredients with antithrombotic properties via virtual screen and experimental studies."Food Chem. 2021 Nov;362:130237 44. [IF=7.727] Xing Pei et al."Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model."J Control Release. 2020 Jun;322:610 43. [IF=9.381] Zhenghui Shi et al."Puff pastry-like chitosan/konjac glucomannan matrix with thrombin-occupied microporous starch particles as a composite for hemostasis."Carbohyd Polym. 2020 Mar;232:115814 42. [IF=13.273] Zhenghui Shi et al."Targeted delivery of hemostats to complex bleeding wounds with magnetic guidance for instant hemostasis."Chem Eng J. 2022 Jan;427:130916 41. [IF=1.134] Song-Bai ZHANG et al."Highly Sensitive Fluorescent Aptasensor for Thrombin Detection Based on Competition Triggered Rolling Circle Amplification."Chinese J Anal Chem. 2015 Nov;43:1688 40. [IF=2.985] Hongwei Wang et al."Anti-complementary activity of two homogeneous polysaccharides from Eclipta prostrata."Biochem Bioph Res Co. 2017 Nov;493:887 39. [IF=3.361] Lingmei Lv et al."Preparation and characterization of a chitin/platelet-poor plasma composite as a hemostatic material."Rsc Adv. 2016 Oct;6(98):95358-95368 38. [IF=4.464] Fang Yuan et al."Split photoelectrochemistry for the immunoassay of α-fetoprotein based on graphitic carbon nitride."J Electroanal Chem. 2016 Dec;783:226 37. [IF=6.232] Guang-Li Wang et al."Fluorescent aptamer-based assay for thrombin with large signal amplification using peroxidase mimetics."Microchim Acta. 2016 Feb;183(2):765-771 36. [IF=6.558] Yuanhong Xu et al."Multifunctional solid-state electrochemiluminescent chemosensors and aptasensor with free-standing active sites based on task-specific pyrene-terminated polymers via RAFT polymerization."Anal Chim Acta. 2018 Dec;1039:31 35. [IF=6.785] Lu-Yi Jin et al."Versatile and Amplified Biosensing through Enzymatic Cascade Reaction by Coupling Alkaline Phosphatase in Situ Generation of Photoresponsive Nanozyme."Anal Chem. 2015;87(20):10429–10436 34. [IF=7.1] Xin Fang et al."Tuning surface states to achieve the modulated fluorescence of carbon dots for probing the activity of alkaline phosphatase and immunoassay of α-fetoprotein."Sensor Actuat B-Chem. 2018 Mar;257:620 33. [IF=7.1] Ping Li et al."A novel strategy for amplified probing versatile biomolecules through a photoswitchable biocatalytic cascade."Sensor Actuat B-Chem. 2018 Jun;262:110 32. [IF=7.46] Hong Wang et al."Ferricyanide stimulated cathodic photoelectrochemistry of flower-like bismuth oxyiodide under ambient air: A general strategy for robust bioanalysis."Sensor Actuat B-Chem. 2019 Jun;288:683 31. [IF=7.79] Yaping Zhong et al."Water-soluble MoS2 quantum dots for facile and sensitive fluorescence sensing of alkaline phosphatase activity in serum and live cells based on the inner filter effect."Nanoscale. 2018 Nov;10(45):21298-21306 30. [IF=8.198] Qing Li et al."Biodegradable Microporous Starch with Assembled Thrombin for Rapid Induction of Hemostasis."Acs Sustain Chem Eng. 2019;7(10):9121–9132 29. [IF=9.594] Fushuang Niu et al."Electrochemically generated green-fluorescent N-doped carbon quantum dots for facile monitoring alkaline phosphatase activity based on the Fe3+-mediating ON-OFF-ON-OFF fluorescence principle."Carbon. 2018 Feb;127:340 28. [IF=10.257] Xue–Lian Hu et al."Switchable fluorescence of gold nanoclusters for probing the activity of alkaline phosphatase and its application in immunoassay."Biosens Bioelectron. 2016 Mar;77:666 27. Tian, Li, Wenke Zhou, and Youhong Zhang. "Construction of a genetically engineered strain of nattokinase and assessment of its fibrinolytic activity." African Journal of Microbiology Research 13.27 (2019): 488-499.https://doi.org/10.5897/AJMR2019.9181 26. Ping, et al. "A novel strategy for amplified probing versatile biomolecules through a photoswitchable biocatalytic cascade." Sensors and Actuators, B. Chemical 262(2018):110-117. 25. Wang, Hongwei, et al. "Anti-complementary activity of two homogeneous polysaccharides from Eclipta prostrata." Biochemical and biophysical research communications 493.2 (2017): 887-893.https://doi.org/10.1016/j.bbrc.2017.09.126 24. Wang, Guang-Li, et al. "Fluorescent aptamer-based assay for thrombin with large signal amplification using peroxidase mimetics."?Microchimica Acta?183.2 (2016): 765-771.https://doi.org/10.1007/s00604-015-1703-5 23. Liu, Yu Xin, et al. "DNA nanosheet as an excellent fluorescence anisotropy amplification platform for accurate and sensitive biosensing." Talanta 211 (2020): 120730.https://doi.org/10.1016/j.talanta.2020.120730 22. 龍繼艷,戴明,鐘瑤,李夢鑫,蔣詠梅.納豆發(fā)酵原料篩選及其功能產(chǎn)品的開發(fā)[J].生物化工,2020,6(06):47-50. 21. 張立強(qiáng),冉茂芳,王松濤,劉光錢,馬卓,任劍波,沈才洪,許濤.瀘州老窖大曲中高產(chǎn)纖溶酶菌株的分離及鑒定[J].釀酒科技,2021(03):17-24. 20. 王常瞵,劉國飛,向澤棟,董萍萍,趙紅金,高鵬,代龍.仿生提取法研究螞蟥不同部位體外抗凝活性[J].山東科學(xué),2020,33(04):13-17. 19. 李秀涼,李倩文,朱玉,韓曉云,孫慶申,宋永.納豆芽孢桿菌發(fā)酵菜用大豆中納豆激酶的提取及其性質(zhì)分析[J].中國釀造,2020,39(12):106-112. 18. 吳雄, 夏建開, 苗艷麗,等. 星點(diǎn)設(shè)計-效應(yīng)面法優(yōu)化復(fù)合酶解酪蛋白制備抗凝血肽的工藝研究[J]. 藥學(xué)研究, 2019, 038(006):P.336-342. 17. 王帥, 郭巧生, 史紅專,等. 短期添加17β-E2對越冬螞蟥生長和性腺發(fā)育的影響. 16. 蘆鑫, 郭巧生, 史紅專,等. 外源甲基睪酮對自然越冬螞蟥生長及性腺發(fā)育的影響. 15. 張旦旦, 竇文芳, 趙軍,等. 重組瑞替普酶在畢赤酵母中的表達(dá)[J]. 微生物學(xué)通報, 2017(9). 14. 錢澤棟,張佑紅,盧育兵,朱麗娜,田莉.納豆菌的分離篩選與鑒定[J].化學(xué)與生物工程,2018,35(08):41-44. 13. 趙謀明,鄒穎,林戀竹,吳見.納豆菌液態(tài)發(fā)酵蕎麥產(chǎn)納豆激酶及其代謝特性分析[J].食品科學(xué),2019,40(04):178-185. 12. 張星燦.納豆激酶在腐乳儲藏條件下穩(wěn)定性初探[J].中國調(diào)味品,2015,40(02):72-76+80. 11. 何夢雪, 李澤友. 海南菲牛蛭抗凝血酶成分的提取與SDS-PAGE電泳測定[J]. 熱帶生物學(xué)報, 2019, 010(002):204-207. 10. 張科衛(wèi), 鐘雨佶, 曹虹虹,等. 水蛭炮制前后質(zhì)量分析[J]. 中成藥, 2018, 40(10):134-139. 9. 王正俊, 李博, 郭立瑋,等. 影響胃蛋白酶和胰蛋白酶纖溶活性因素初探及其纖溶活性失活研究[J]. 中草藥, 2016, 47(01):56-66. 8. 王立, 張坤, 鄒燁,等. 超聲輔助提取對雞肝蛋白結(jié)構(gòu)及功能特性的影響[J]. 江蘇農(nóng)業(yè)學(xué)報, 2018, 034(005):1153-1160. 7. 蔣曉煌,蔣孟良,賀衛(wèi)和,曾婷,劉瑩,孟珠,趙梓含,鄧瀟瀟.膠艾湯不同炮制組方對動物子宮收縮、凝血酶原時間與纖溶活性的影響[J].中國醫(yī)院藥學(xué)雜志,2017,37(09):835-838. 6. 張松柏, 鄭麗英, 胡霞,等. 基于競爭觸發(fā)滾環(huán)擴(kuò)增的熒光適配體傳感器高靈敏檢測凝血酶[J]. 分析化學(xué), 2015, 000(011):1688-1694. 5. 林陳水 陳微微. 分泌型水蛭素Ⅱ基因工程菌的構(gòu)建[J]. 浙江工業(yè)大學(xué)學(xué)報 2014 42(1):50-53. 4. 王常瞵 劉國飛 向澤棟 等. 仿生提取法研究螞蟥不同部位體外抗凝活性[J]. 山東科學(xué) 2020(4):13-17. 3. 田莉 盧軼男 朱建 等. 產(chǎn)納豆激酶的枯草芽孢桿菌基因工程菌發(fā)酵條件的響應(yīng)面優(yōu)化[J]. 武漢工程大學(xué)學(xué)報 2018 v.40;No.209(06):33-40. 2. 尹夢雯 周倩 雷嬋 等. 產(chǎn)纖溶酶乳酸菌篩選及安全性評估[J]. 食品與機(jī)械 2017 033(010):28-33. 1. 白景芝 劉永杰. IL-6 RF ACCP及凝血指標(biāo)在冠心病合并類風(fēng)濕關(guān)節(jié)炎患者中的表達(dá)及意義[J]. 中國衛(wèi)生工程學(xué) 2020 v.19(03):142-144.