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鵝去氧膽酸

    
分析標準品,HPLC≥98%

Chenodeoxycholic acid

源葉
B20347 一鍵復制產品信息
474-25-9
C24H40O4
392.58
MFCD00064142
脫氧鵝膽酸;鵝脫氧膽酸;3α,7α-二羥基膽質酸;3α,7α-二羥基-5-β-膽烷酸
貨號 規格 價格 上海 北京 武漢 南京 購買數量
B20347-20mg
分析標準品,HPLC≥98% ¥200.00 >10 2 5 1
產品介紹 參考文獻(39篇) 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

鵝去氧膽酸是一種疏水初級膽汁酸,能夠活化核受體 FXR,該受體與膽固醇代謝有關。

生物活性: Chenodeoxycholic Acid 是一種疏水初級膽汁酸,能夠活化核受體 FXR,該受體與膽固醇代謝有關。鵝去氧膽酸(CDCA)和脫氧膽酸(DCA)均能抑制11 beta HSD2,IC50值分別為22mM和38mM,并引起皮質醇依賴性核易位,增加鹽皮質激素受體(MR)的轉錄活性。鵝去氧膽酸能夠通過激活膜G蛋白偶聯受體(TGR5)依賴途徑,誘導細胞周期蛋白d1蛋白和mRNA表達的顯著增加,從而刺激Ishikawa細胞的生長。鵝去氧膽酸(CDCA)在培養的人肝母細胞瘤細胞系HepG2中誘導低密度脂蛋白受體mRNA水平約為4倍,高密度脂蛋白輔酶A還原酶和高密度脂蛋白輔酶A合成酶的mRNA水平為2倍。氯去氧膽酸誘導的ISC(≥67%)被布美他尼、Bacl2和囊性纖維化跨膜電導調節器(CFTR)抑制劑cftrinh-172抑制。腺苷酸環化酶抑制劑MDL12330A使鵝去氧膽酸刺激的ISC降低43%,鵝去氧膽酸增加細胞內cAMP濃度。鵝去氧膽酸處理激活c/ebpβ,如其磷酸化、核積累和在hepg2細胞中的表達增加所示。Chenodeoxycholic acid增強含有-1.65-kb GSTA2啟動子的構建體的熒光素酶基因轉錄,該啟動子含有C / EBP反應元件(pGL-1651)。鵝去氧膽酸處理激活AMP激活蛋白激酶(AMPK),導致細胞外信號調節激酶1/2(ERK1/2)激活,實驗結果證明了使用AMPKα的顯性負突變體和化學抑制劑。

熔點: 165-167°C
沸點: 547.1 °C at 760 mmHg
比旋光度: 12 o (c=1, CHCl3)
外觀: 白色粉末
溶解性: 幾乎不溶于水,易溶于乙醇、冰乙酸、微溶于氯仿。
敏感性: 對光敏感
儲存條件: 2-8℃
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻(39篇)

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[IF=4.9] Huang Hefei et al."Tanreqing injection inhibits dengue virus encephalitis by suppressing the activation of NLRP3 inflammasome."Chinese Medicine".2024 Dec;19(1):1-17 29. [IF=5.6] Shengyun Dai et al."Synergistic effect of Euphorbia kansui stir-fried with vinegar and bile acids on malignant ascites effusion through modulation of gut microbiota."Frontiers in Pharmacology.2023; 14: 1249910 28. [IF=3.9] Ya-nan Ou-Yang et al."High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats."BIOCHIMIE.2023 Oct;: 27. [IF=6.1] Sensen Chi et al."Time-restricted feeding alleviates metabolic implications of circadian disruption by regulating gut hormone release and brown fat activation."Food & Function.2023 Oct;: 26. 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[IF=7.675] Lei Xu et al."Chenodeoxycholic Acid (CDCA) Promoted Intestinal Epithelial Cell Proliferation by Regulating Cell Cycle Progression and Mitochondrial Biogenesis in IPEC-J2 Cells."Antioxidants.2022 Nov;11(11):2285 21. [IF=4.571] Yuanjie Wen et al."The role of the farnesoid X receptor in quadruple anti-tuberculosis drug-induced liver injury."TOXICOLOGY.2022 Jun;476:153256 20. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 19. [IF=5.396] Juan Wu et al."Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes."Food Funct. 2022 Feb;: 18. [IF=3.935] Runjing Zhang et al."Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics."J Pharmaceut Biomed. 2020 Feb;179:112966 17. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 16. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 15. [IF=5.34] Kaihui Zhang et al."A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis."Phytomedicine. 2021 Oct;91:153683 14. 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[IF=3.935] Ziying Liu et al."Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma."J Pharmaceut Bio 9. 曹妍,李婷,常安琪,蔣珍珍,于娟,屠鵬飛,宋月林.蛇膽中膽汁酸類化學成分分析[J].中國中藥雜志,2021,46(01):130-138. 8. 李瑋,蔣珍珍,李菡,屠鵬飛,宋青青,于娟,宋月林.利用在線加壓溶劑提取-超高效液相色譜-離子阱-飛行時間-質譜法定性分析片仔癀化學成分組[J].色譜,2021,39(05):478-487. 7. 曹妍, 宋青青, 李軍,等. 牦牛膽中膽汁酸類化學成分分析[J]. 中國中藥雜志 2019年44卷12期, 2538-2543頁, MEDLINE ISTIC PKU CSCD CA BP, 2019. 6. 陳云, 陳勁松, 郁紅禮,等. 膽南星發酵制品與混合蒸制品的鑒別研究[J]. 世界中醫藥, 2019, v.14(02):42-45+50. 5. 陳云 郁紅禮 吳皓 等. 發酵對膽南星中膽汁酸類成分的影響及膽南星中3種游離膽汁酸含量測定研究[J]. 中國中藥雜志 2018 43(22):99-103. 4. 陳江寧, 單國順, 劉曉瑜,等. 膽南星輔料成分分析及其清熱作用[J]. 中國現代中藥 2016年18卷7期, 837-840頁, ISTIC CA, 2016. 3. 席曉志, 李佳, 郭莎莎,等. 鵝去氧膽酸的大孔樹脂純化工藝優化及其降血脂活性[J]. 現代食品科技, 2018, 034(008):123-129. 2. 趙啟苗, 單國順, 陳江寧,等. 膽南星質量評價方法初探[J]. 中國實驗方劑學雜志, 2017(06):28-31. 1. 陳江寧 單國順 趙啟苗 等. 不同膽汁制膽南星中膽酸類成分及其解熱作用比較[J]. 現代藥物與臨床 2017 32(004):567-571.

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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