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 1、NATURE NEUROSCIENCE（IF=28.771）

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摘要：Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the formation of lipid-accumulated reactive astrocytes (LARAs), a new reactive astrocyte subtype characterized by elevated APOE expression. Genetic knockout of APOE inhibited LARA formation and seizure activities in epileptic mice. Single-nucleus RNA sequencing in TLE patients confirmed the existence of a LARA subpopulation with a distinct molecular signature. Functional studies in epilepsy mouse models and human brain slices showed that LARAs promote neuronal hyperactivity and disease progression. Targeting LARAs by intervention with lipid transport and metabolism could thus provide new therapeutic options for drug-resistant TLE.

文獻鏈接：https://www.nature.com/articles/s41593-023-01288-6

2、APPLIED CATALYSIS B-ENVIRONMENTAL（IF=24.319）

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摘要：Conversing proteinaceous enzyme behavior into nanomaterials is intriguing academically, but the threshold from mimicry to accessing sophisticated biological entities has not yet been crossed. Herein, we disclosed the pan-glycoside hydrolases-like (p-GHs-like) activities of Cu3P and Cu2O nanoparticles and decently confirmed their consistent catalytic mechanism as natural glycoside hydrolase, that is, the precise bond breaking, anomeric carbon configuration and catalytic attack mode. We then introduced p-GHs-like NPs into Escherichia coli to establish a feedback regulatory model for the β-D-glucuronidase (expressed by uidA) that was initially expressed in trace amounts. An upregulation of uidA from 72 to 1000 counts was induced by the p-GHs-like activities via pre-released β-glucuronides derivatives, further contributing to 1–2 orders enhancement of the enzyme production. We unearthed the specific catalytic mechanism to unlock a black box of enzyme-like inorganic feedback on the natural enzyme synthesis process, pushing mimicry leaped to physiological behavior.

文獻鏈接：https://www.sciencedirect.com/science/article/pii/S0926337323002825

3、PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA（IF=12.779）

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摘要：Smart pesticides that respond to environmental stimuli can achieve the on-demand release of pesticides to control pests and diseases, thereby reducing the amount of pesticides used, and reducing the risk to the environment. In this study, a pH/cellulase dual stimuli-responsive controlled-release pesticide formulation (PYR@UiO-66@HPC) was successfully fabricated by encapsulating pyraclostrobin (PYR) and coating hydroxypropyl cellulose (HPC) within a metal–organic framework (MOF, i.e., UiO-66). The obtained results demonstrated that PYR@UiO-66@HPC exhibited an excellent PYR release behavior in response to acidic and cellulase environments similar to the environment at the time of Rhizoctonia solani infestation. In addition, PYR@UiO-66@HPC exhibited a higher fungicidal activity than commercial microencapsulated formulations, and biosafety tests showed that PYR@UiO-66@HPC had less effect on non-target organisms, especially on Daphnia magna, with a toxicity of 4.6 times lower than that of PYR-TC after 48 h. Furthermore, it did not affect the normal growth of the target rice crop and had a low impact on the soil microbial community. Finally, cytotoxicity assays showed that PYR@UiO-66@HPC had little effect on cell proliferation and apoptosis in LO2 cells compared with the free PYR, thereby indicating a superior biocompatibility and an improved human safety profile. This study therefore provides a smart, eco-friendly, and sustainable strategy for the effective control of plant diseases.

文獻鏈接：https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202212231